Endocrine Abstracts

Introduction: Acromegaly is a chronic disease characterized by prognatism, frontal bossing, coarsened facial features, enlarged hands and feet due to overproduction of growth hormone (GH) generally by a pituitary adenoma. Here, we aimed to present an acromegalic patient presented with retropharyngeal hypertrophy first time in the literature.Case report: 65-year-old female patient had been referred to our department from otorhinolaryngology outpatient-cli...

Introduction: Amyloidosis is characterised by accumulation of amorph and proteinous substance in several tissues and organs. Thyroid, adrenal, and pituitary insufficiencies may rarely be observed due to accumulation of these substances. Here, we present a case to point out this rare condition.Case report: A 19-year-old male patient admitted with complaints of swelling in the neck, abnormality in thyroid hormone levels and fatigue. He had been diagnosed w...

Aim: Obstructive sleep apnea syndrome (OSAS) has been studied rarely in patients with Cushing’s syndrome. We investigated the possible association between Cushıng’s syndrome and OSAS in this study.Method: Thirty female patients with newly diagnosed Cushing’s syndrome and 30 female obese control subjects were included in this study. All the participants were evaluated by polysomnography. OSAS was defined as apneahypopnea index (AHI) of...

Introduction: Warthin-like papillary thyroid carcinoma (WLPTC) is a rare variant of thyroid papillary carsinoma (TPC). We present these cases to point out this rare variant.Case reports: Case 1: A 38-year-old woman admitted to outpatient clinic with a thyroid nodule. Ultrasonography of thyroid gland revealed bilateral multinodular goiter with microcalcifications. Thyroid autoantibodies were elevated. Thyroid function tests (TFT) were normal. Fine-needle ...

Introduction: Despite having different embriogenic origins, thyroid medullary carcinoma and follicular carcinoma may be seen together as mixed medullary-follicular thyroid carcinoma. We present a rare case of mixed medullary-follicular cell carcinoma of thyroid which has a progressive and aggressive nature.Case report: A 68-year-old female patient admitted with complaint of a lump in her neck. Ultrasonography of thyroid gland revealed a 37×35 mm sol...

Aim: Thyroid papillary carcinomas smaller than 1 cm are called papillary microcarcinomas (PMC). They rarely metastasize to lymph node (LN) and distant areas. The presence of palpable lymphadenopathy at the time of diagnosis shows high risk of recurrence regardless of primary tumor size. We aimed to investigate histopathologic characteristics and recurrence frequency of thyroid PMCs with LN metastasis (LNM).Materials and methods: Thyroid PMC cases with LN...

Introduction: Osteogenesis imperfecta (OI) is a congenital, generalized connective tissue disorder characterized by severe osteoporosis and bone fragility. OI is most commonly caused by mutations in genes encoding the α-1 and α-2 chains of type I collagen or proteins involved in posttranslational modification of type I collagen. Although, no controlled studies are done, bisphosphonates are used for the treatment of OI. I.v. bisphosphonates are reported to be more eff...

Introduction: Adrenocortical carcinoma (ACC) is a rare cancer (estimated incidence, 0.7 to 2.0 cases per 1 million population per year) with a poor prognosis. Even after seemingly complete surgical resection, most patients develop recurrence within 5 years. The 5-year survival rate is <15% among patients with metastatic disease.Methods: We present the results of six patients with adrenocortical carcinoma followed in our clinic....

Introduction: Acromegaly is a disease caused by excessive secretion of GH. The cause of acromegaly is GH secreting pituitary adenoam in 99% of the cases. It is estimated that 5% of pituitary adenomas become invasive and may grow to gigantic sizes (>4 cm in diameter). Here, we present a 31 years old acromegalic woman with a delayed diagnosis of a giant invasive pituiatary adenoma.Case report: A 31-year-old woman admitted to our hospital for oligomenor...

Introduction: Vascular endothelial growth factor (VEGF) is a specific mitogen for endothelial cells. Granulocyte–monocyte colony stimulating factor (GM-CSF) is a key player in the regulation of steady-state functions. Studies have shown increased levels of VEGF and GM-CSF in benign and malignant tumors. The aim of this study was to evaluate the relation between VEGF and GM-CSF levels and thyroid nodules >1 cm. and negative for malignancy with fine needle aspiration bi...